deleterious effect upon reproductive success and so persists for a hundred generations, an estimate of three new mutations per generation yields the depressing conclusion that the average newly conceived human bears three hundred mutations that impair its health in some fashion. No one completely escapes thismutational storm. But – and this is necessarily true – we are not all equally subject to its force. Some of us, by chance, are born with an unusually large number of mildly deleterious mutations, while others are born with rather few. And some of us, by chance, are born with just one mutation of devastating effect where most of us are not. Who, then, are the mutants? There can be only one answer, and it is one that is consistent with our everyday experience of the normal and the pathological. We are all mutants. But some of us are more mutant than others.
II
A PERFECT JOIN
[O N THE INVISIBLE GEOMETRY OF EMBRYOS ]
I n the volume of engraved plates that accompanies the report of their dissection, Ritta and Christina Parodi appear as a pair of small, slender, and quite beautiful infant girls. They have dark eyes, and their silky curls are brushed forward over their foreheads in the fashion of the French Empire, in a way that suggests a heroic portrait of Napoleon Bonaparte. Their brows and noses are straight, their mouths sweetly formed, and their arms reach towards each other, as if in embrace, but their expressions are conventionally grave. Distinct from the shoulders up, their torsos melt gradually into each other; below the single navel the join is so complete that they have, between them, one vulva, one rectum, one pelvis, and one pair of legs. It is a paradoxical geometry. For although the girls are, individually, so profoundly deformed, together they are symmetrical and proportionate; their construction seems less an anomaly of nature than its designed result. It may be thought that this beauty is merely a product of the engraver’s art, but a plaster-cast of their body shows the same harmony of form. If the engraver erred it was only in giving them the proportions of children older than they were; they were only eight months old when they died.
C ONJOINED TWINS: PYGOPAGUS . J UDITH AND H éLèNE (1701–23). F ROM G EORGE L ECLERC B UFFON 1777
Histoire Naturelle GéNéRale Et ParticulièRe.
C ONJOINED TWINS: PARAPAGUS DICEPHALUS TETRABRACHIUS . R ITTA AND C HRISTINA P ARODI (1829). F ROM É TIENNE S ERRES 1832
Recherches d’anatomie transcendante et pathologique.
THE APOTHEOSIS OF RITTA-CHRISTINA
The Parodis arrived in Paris in the autumn of 1829. Six months previously they had left Sassari, a provincial Sardinian town, in the hope of living by the exhibition of their children. Italy had been receptive; Paris was not. Local magistrates, ruling on the side of public decency, forbade the Parodis to show their children to the multitude and so deprived them of their only income. They moved to a derelict house on the outskirts of the city, where they received some payment from a procession of physicians and philosophers who came to see the children in private.
What they earned wasn’t even enough to heat the house. The
savants
, puzzling over what they found, were also continually uncovering the children. Was there one heart or two? The stethoscope gave conflicting results. They were fascinated by the differences between the children. Christina was a delight – healthy, vigorous, with a voracious appetite; Ritta, by contrast, was weak, querulous and cyanotic. When one fell asleep the other would usually do so as well, but occasionally one slept soundly while the other demanded food. Continually exposed to chills, Ritta became bronchitic. The physicians noted that sickness, too, demonstrated the dual and yet intertwined nature of the girls, for even as Ritta gasped for air, her sister lay at her side unaffected and content. But three minutes after Ritta died, Christina gave a cry and her hand, which was in
II
A PERFECT JOIN
[O N THE INVISIBLE GEOMETRY OF EMBRYOS ]
I n the volume of engraved plates that accompanies the report of their dissection, Ritta and Christina Parodi appear as a pair of small, slender, and quite beautiful infant girls. They have dark eyes, and their silky curls are brushed forward over their foreheads in the fashion of the French Empire, in a way that suggests a heroic portrait of Napoleon Bonaparte. Their brows and noses are straight, their mouths sweetly formed, and their arms reach towards each other, as if in embrace, but their expressions are conventionally grave. Distinct from the shoulders up, their torsos melt gradually into each other; below the single navel the join is so complete that they have, between them, one vulva, one rectum, one pelvis, and one pair of legs. It is a paradoxical geometry. For although the girls are, individually, so profoundly deformed, together they are symmetrical and proportionate; their construction seems less an anomaly of nature than its designed result. It may be thought that this beauty is merely a product of the engraver’s art, but a plaster-cast of their body shows the same harmony of form. If the engraver erred it was only in giving them the proportions of children older than they were; they were only eight months old when they died.
C ONJOINED TWINS: PYGOPAGUS . J UDITH AND H éLèNE (1701–23). F ROM G EORGE L ECLERC B UFFON 1777
Histoire Naturelle GéNéRale Et ParticulièRe.
C ONJOINED TWINS: PARAPAGUS DICEPHALUS TETRABRACHIUS . R ITTA AND C HRISTINA P ARODI (1829). F ROM É TIENNE S ERRES 1832
Recherches d’anatomie transcendante et pathologique.
THE APOTHEOSIS OF RITTA-CHRISTINA
The Parodis arrived in Paris in the autumn of 1829. Six months previously they had left Sassari, a provincial Sardinian town, in the hope of living by the exhibition of their children. Italy had been receptive; Paris was not. Local magistrates, ruling on the side of public decency, forbade the Parodis to show their children to the multitude and so deprived them of their only income. They moved to a derelict house on the outskirts of the city, where they received some payment from a procession of physicians and philosophers who came to see the children in private.
What they earned wasn’t even enough to heat the house. The
savants
, puzzling over what they found, were also continually uncovering the children. Was there one heart or two? The stethoscope gave conflicting results. They were fascinated by the differences between the children. Christina was a delight – healthy, vigorous, with a voracious appetite; Ritta, by contrast, was weak, querulous and cyanotic. When one fell asleep the other would usually do so as well, but occasionally one slept soundly while the other demanded food. Continually exposed to chills, Ritta became bronchitic. The physicians noted that sickness, too, demonstrated the dual and yet intertwined nature of the girls, for even as Ritta gasped for air, her sister lay at her side unaffected and content. But three minutes after Ritta died, Christina gave a cry and her hand, which was in
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